Stats Direct

STATs and macrophage fusion

Macrophages play a pivotal role in host defense against multiple foreign materials such as bacteria, parasites and artificial devices. Some macrophage lineage cells, namely osteoclasts and foreign body giant cells (FBGCs), form multi-nuclear giant cells by the cell-cell fusion of mono-nuclear cells. Osteoclasts are bone-resorbing cells, and are formed in the presence of RANKL on the surface of ...

STATS 375 - Project Proposal

Belief propagation is a message-passing algorithm for performing inference in graphical models that has been implemented in a variety of domains including artificial intelligence, information theory and statistical physics. As we know, BP provides exact results only on a relatively restrictive subclass of problems, when the graphical model is a tree (or more generally if each connected componen...

JAKs, Stats, and CK2?

derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity. Activating mutations in JAK2, a tyrosine kinase that serves as a critical signaling protein for multiple cytokines, are associated with BCR-ABL1–negative myelo-proliferative neoplasms. In this issue of Blood, Zheng and colleagues report that the constitutively activated kinase CK2 binds to JAK2 and is required fo...

Dictyostelium development: Lower STATs

The discovery of a STAT protein in Dictyostelium indicates that this organism uses phosphotyrosine-SH2-domain signalling during development. Such signalling is lacking in yeast and its appearance may therefore be an early step in the evolution of multicellularity.

STATS 300C Homework 5